Background: The pre anesthetic medication forms an integral part of anesthetic management. Some form of premedication is almost universally given before induction of anesthesia. In ancient days both wine and opium were given to lessen the fear of surgery. Objective: To assess the Compliance and Sedation Score of Intranasal Midazolam and dexmedetomedine Premedication among Children between 1 to 5 years of age. Methodology: A longitudinal study was conducted from June 2012 to December 2012 at Department of Anesthesiology of Shri M.P. Shah Medical College, Jamnagar, Gujarat. A total of 30 Cases were selected based on age sex matched with each group for the purpose of the study randomly as per the computer generated random Numbers. Group 1 received intranasal midazolam spray and Group 2 was given intranasal dexmedetomedine. Results: The sedation score was found to be statistically significant at 30 and 45 min post induction. Postoperative recovery score at 30 min was found to statistically highly significant with suggested that postoperative recovery score was better in group 1 as compared to group 2. Conclusion: Intranasal dexmedetomidine spray better sedative condition, response to IV cannulation, separation and induction as compared to intranasal midazolam in majority of patients. This study concludes that intranasal dexmedetomedine is better than intranasal midazolam as premedication in pediatric patients.