Aim: To compare the effectiveness of mouth dissolving antiemeticsprochlorperazine and granisetron in the prevention of postoperative nausea and vomiting in patients undergoing abdominal hysterectomy under spinal anaesthesia Materials and Methods: A total number of 50 cases of ASA Gr.I and Gr. II were taken into a double blind randomized study and divided into two groups. 25 of them received Granisetron 1mg mouth dissolving tablet and the other 25 patients received Prochlorperazine 5mg mouth dissolving tablet for preventing postoperative nausea and vomiting and observed for a period of 24 hours. Results: There were no statistically significant differences between the groups with respect to patient characteristics, type of surgery and duration of anesthesia. Administration of Prochlorperazine and Granisetron 60min before surgery, effectively controlled nausea and vomiting during early postoperative period i.e., within 6 hours after surgery. Postoperative nausea and vomiting in the 6 – 24 hours postoperative period was significantly lower with Granisetron when compared to Prochlorperazine. (p value <0.01) Conclusion: Administration of Granisetron 1hr before surgery was superior to Prochlorperazine in long term prevention of postoperative nausea and vomiting following Total abdominal hysterectomy under spinal anesthesia.