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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4417.50

Abstract

Introduction: Laryngoscopy and endotracheal intubation causes transient circulatory changes and are marked by tachycardia, hypertension and sometimes cardiac arrhythmias. Aims and Objective: This study was designed to compare the effectiveness of oral Gabapentin in two different doses of 800mg and 1200mg on hemodynamic response during laryngoscopy and endotracheal intubation. Method: After hospital ethics committee permission,100 patients of either sex, 18-60 years, ASA grade one, weighing 40-70 kg posted for elective surgery under general anaesthesiawere included. Group Areceived 800 mg of Gabapentin and Group B received 1200 mg of Gabapentin orally two hours prior to surgery randomly. The allocation sequence was in sealed opaque envelopes. After 90 seconds of injection Rocuronium, endotracheal intubation was performed by an anaesthetist of the level of senior resident. For each patient heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded before induction of anaesthesia, after induction of anaesthesia, immediately after endotracheal intubation at 0,1,3,5 and 10 minutes. Statistical analysis was summarized as mean and standard deviation. Results: In Group A, mean heart rate and arterial pressure increased at 0, 1, 3, 5 and 10 minutes of laryngoscopy and intubation while in Group B there was no significant change. When two groups were compared, the difference between the mean heart rate and mean arterial pressure after was statistically significant (p < 0.001). When the mean heart rate and arterial blood pressure after intubation was compared with pre induction, an increasing trend was seen in Group A at 0,1,3, 5,10 min of intubation.( p <0.001 ). In Group B, the change in the mean heart rate at 0 min after intubation was significant (p = 0.027 ) and change in the mean arterial pressure after intubation at 1 min ( p = 0.029 ) , 3 min (p = 0.021 ) and 10 min ( p = 0.014 ) was significant. Conclusion: Oral Gabapentin 1200 mg when given two hours prior to surgery was better in attenuating the pressor response to laryngoscopy and intubation as compared to oral Gabapentin 800 mg.

Keywords : Oral Gabapentin; Laryngoscopy; Intubation; Pressor Response. 

Corresponding Author : Vaishali A. Mohod, Associate Professor, Department of Anaesthesiology and Critical Care, Grant Government Medical College and Sir J J Group of Hospitals, Byculla, Mumbai, Maharashtra 400008, India.