AbstractBackground and Aims: Intraperitoneal instillation of local anaesthetics is one of the recent techniques to minimize post-operative pain after laparoscopic surgeries. We compared the effects of intraperitoneal instillation of ropivacaine dexmedetomidine combination with that of intraperitoneal ropivacaine alone in patients undergoing laparoscopic cholecystectomies. Methods: A total of 120 patients participated in this prospective, randomized, doubleblinded study. Patients were divided into two study groups(n=60) randomly and received intraperitoneal instillation of ropivacaine (0.25%) 50 ml in Group R and ropivacaine with dexmedetomidine 1 g/kg, (diluted to 50ml volume with normal saline) in Group RD at the end of surgery under sterile precautions. Visual analogue scale score (VAS) was used to assess the quality of analgesia at various intervals. Time to the first demand for analgesia, total dose of analgesic used in the first 24 hours and adverse effects if present were noted. Statistical analysis was performed with the Student’s t-test and Chi-square test (level of significance P = 0.05). Results: VAS pain scores at different time intervals was significantly lower, time to first demand analgesia (min) in the post-operative period was increased and total post-operative analgesic consumption (mg) was lesser in group RD than group R. Also, mean heart rate and mean blood pressure were significantly lower in group RD than in group R. There was no statistically significant difference regarding the adverse effects between the groups. Conclusion: End operative intraperitoneal instillation of ropivacaine dexmedetomidine combination is superior to ropivacaine (alone) for post-operative analgesia in laparoscopic cholecystectomy.
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