Context: Dexmedetomidine has been a prime matter of subject studies in research over it with its comparison with various other agents as it possesses properties like sedation and analgesia. Aims: To study the effectiveness of dexmedetomidine in intravenous regional anesthesia. Settings and Design: This is a prospective, randomized, double blind control study conducted at SVS Hospital and Medical College, Mahabubnagar. Methods and Material: In this study totally 60 patients were divided into two groups. We gave 40 ml of Lignocaine with 0.5 microgram/kg Dexmedetomidine in Group LD patients. 40 ml of 0.5% Lignocaine was given for Group L patients. Statistical Analysis: Mean and standard deviation were calculated. Student’s t test was used for statistical analysis. P value of less than 0.05 was taken as statistically significant. Results: Both the groups were comparable in terms of pulse rate, age, duration of surgery, weight, and mean arterial blood pressure. Sensory onset time, motor onset time was significantly lesser in LD group compared to L group. At the same time, motor recovery time and sensory recovery time were significantly more in LD group compared to L group (p<0.05). Duration of post operative analgesia when VAS was more than 3 was significantly more in LD group compared to L group (p<0.05). Conclusion: Dexmedetomidine was found to be very effective in terms of less occurrence of pain of tourniquet, quick onset of motor and sensory blockade, hemodynamic stability, persistence of analgesia post operatively.