Aims and Objectives: To compare the combination new drug dexmedetomidine and bupivacaine with bupivacaine alone in terms of Onset and duration of sensory, and motor blocks, Duration of analgesia, Hemodynamic parameters and adverse effects. A prospective randomised double blind study done on 60 patients posted for various upper limb surgeries. They divided in two groups each including 30 patients, in which Group B received Bupivacaine 0.25% (30 cc) + 1ml normal saline. Group D received Bupivacaine 0.25% (30 cc)+ Dexmedetomidine 1 mg/kg + normal saline to make a total 31 ml. supraclavicular block given using peripheral nerve stimulator. We observed that, Demographic data and surgical characteristics were comparable in both the groups. The onset times for sensory and motor blocks were significantly shorter in B than A group (P < 0.001). Duration of blocks was significantly longer (P < 0.001) in B group. The duration of analgesia was significantly longer in B group than a group (P < 0.001). Hemodynamic parameters like HR, SBP, and DBP were lower in group B. We conclude that, Dexmedetomidine at the dose of 1 ug/kg body weight added as an adjuvant to 0.25% bupivacaine in supraclavicular brachial plexus block in upper limb surgeries is highly effective in prolongation of sensory analgesia and provides better post operative analgesia. So, the patients remain comfortable in the post operative period with considerable therapeutic benefit & without any potential side effects.