This study designed to test the hypothesis that the preoperative use of pregabalin will reduce th consumption of analgesics after laparoscopic cholecystectomy and to compare its efficacy and side effects with that of gabapentin. It is observed that preoperative single-dose pregabalin (150mg) was comparable to gabapentin (300mg) in reducing both the static and the dynamic components of postoperative pain along with postoperative analgesic consumption in subjects undergoing laparoscopic cholecystectomy. A decrease in VAS pain scores was found in patients who received pregabalin one hour before surgery in comparison to patients who received gabapentin. Although pregabalin was found more effective than gabapentin in the present study, usage of both was associated with decreased analgesic consumption. In conclusion, oral Pregabalin 150 mg administered before surgery was effective than Gabapentin 300mg in reducing postoperative pain and postoperative analgesic consumption in patients undergoing laparoscopic cholecystectomy. Gabapentin and Pregabalin, both can be an effective tool in the armamentarium of  anaesthesiologist in treatment of postoperative pain. They can be used as part of multimodal therapy if not as sole analgesic.