Background: Post operative nausea and vomiting following laparoscopic cholecystectomy is a common complication. This study was designed to analyze and compare efficacy and adverse effect of ramosetron and granisetron in prevention of post operative nausea and vomiting following laparoscopic cholecystectomy. Method: 100 patients of American Society of Anesthesiologists class I­II, aged 25 to 55 years scheduled for laproscopic cholecystectomy were included in study. Patients with history of smoking, drug or alcohol abuse, known allergy to granisetron or ramosetron, impaired kidney or liver function, motion sickness and history of previous post­operative nausea and vomiting, or those who received antiemetics within 24 hours before scheduled surgery, menstruating, pregnant or lactating women, or those on whom laparoscopic cholecystectomy was converted into open cholecystectomy were excluded from the study. 100 patients were divided into 2 groups of group A and Group B of 50 patients each. Group A patients received 2 mg of granisetron diluted to make 4ml in normal saline and group B patients received 0.3 mg of ramosetron diluted to make 4ml in normal saline given at the end of surgery Results: No significant statistical difference seen immediately after extubation and 0 to 6 hrs and 6 to 12 hrs. but statistically significant result was observed 12 to 18 and 18 to 24 after surgery. Conclusion: Ramosetron provides prolonged relief from post operative nausea vomiting as compared to granisetron in laproscopic cholecystectomy .

Keywords: Granisetron; Ramosetron; Laproscopic Cholecystectomy; Nausea Vomiting