Background: Considering that TB, as well as MDR-TB, are related to social inequalities, it is important that interventions be founded not only on the clinical- epidemiological profile of the population, but also on the socio-demographic profile, in order to make the interventions pertinent and effective. Methodology: It was a cross sectional, hospital based study among MDR-TB patients admitted in DR-TB Centre, Bellary, during the period between Jan 2013 to July 2013. Results: A total of 66 patients were interviewed and examined. Among them 75.6% belonged to 21-40 years of age group, 87.9% were from class IV & class V socio-economic group according to modified B.G. Prasad classification. Smoking was the most common co-morbidity. 47% of them exposed to ATT in the past for 1-2 years and 98.5% patient’s last ATT outcome was treatment completed. Among them 78.8% were resistant to both rifampicin and isoniazid. Most (59.1%) belonged to 26-45 kg weight band. The knowledge and practices regarding MDR-TB was good among them. Conclusion: Proper follow up was not done during past ATT, which led to MDR-TB. Health education regarding spread of disease, early detection of MDR-TB by strengthened laboratory support, effective therapy, implicating innovative control measures, would interrupt the ongoing transmission and control this emerging epidemic.