Osteoporosis is a systematic skeletal disorders characterized by compromised bone strength predisposing to an increasing risk of bone fracture. This study was undertaken to assess the knowledge regarding osteoporosis and its prevention among 200 women attending selected OPD’s of Medical College Hospital, Ernakulam district, Kerala. Quantitative approach and descriptive survey was used in the study. The data was tabulated and analyzed using differential and inferential statistics like frequency, percentage and chi-square test. The conclusion drawn from the study had shown that 54 % had average knowledge regarding prevention of osteoporosis among women. There is an immense need of creating awareness among women regarding prevention of osteoporosis in order to make positive lifestyle changes.