We report a case of 65-year-old man undergoing an elective face lift operation. He was taking Tamsulosin 0.8 mg OD and Dutasteride 0.5 mg OD since last 2 years for benign prostatic hypertrophy (BPH). Tamsulosin, a á-1 selective adrenergic receptor (á-1-AR) antagonist, is used as first-line drug for BPH. He developed persistent hypotension during the maintenance phase of anaesthesia while receiving O2/N2O and 1% Isoflurane. High index of vigilance for unexpected hypotension is important in patients, who are treated with selective á- 1-AR blockers, undergoing surgery. If hypotension occurs, vasopressors that act directly on á-1-AR could be more effective.