Liver abscess continues to remain a surgical problem with considerable morbidity. Over the years minimally invasive techniques like percutaneous needle aspiration and catheter drainage have gained usage in combination with intravenous antibiotics. Most of the liver abscesses in India are amoebic in etiology. Amoebic liver abscesses generally do not require drainage, amoebicidal agents being effective alone. Hence, these must be distinguished from pyogenic liver abscesses which are not uncommon. Many clinical and laboratory parameters can aid in this differentiation. The aim of this study is to compare the clinical, radiological and biochemical profile of these patients with their bacteriological, parasitological and serological findings to identify new trends in etiology of liver abscesses and determine the differentiating parameters that can aid in management of these patients.