For many years, the prevailing concept in space human factors research has been that microgravity has an impact on human physiology and astronauts are faced with several health risks during both short and long duration spaceflights. The review of our study found that reversible effect of microgravity is oedema of face, change in taste, abnormal expression of face, teeth pain and xerostomia. The non reversible effects of microgravity such as periodontal disease, dental caries but in different pattern than normal, stone formation in salivary duct, pre cancer or cancer, fracture of maxillary and mandibular bone and xerostomia are more prevalent in astronauts as compared to normal persons. Further study will be required on large scale on long term effects of microgavity on oral cavity to prevent the adverse effects.

Key words: Mars mission, human factors, Microgravity, Aeronautic Dentistry