Primary Non-Hodgkin’s Lymphoma of cranial vault is a rare entity. We came across an interesting case of a 30 year old immunocompetent male who presented to us with a scalp swelling in the left parietal region. Computed tomography (CT) and MRI (Magnetic resonance imaging) of head showed contrast-enhancing lesion in left parietal region. CT scan of patient’s abdomen, chest and pelvis did not reveal any lymphadenopathy or organomegaly. After excision, the histopathology and immunohistochemistry of the lesion confirmed the diagnosis of Diffuse Large B cell Lymphoma. Patient was further treated with chemotherapy and radiotherapy with complete resolution of the lesion. The rarity of the condition with a good response to treatment combining surgery, chemotherapy and radiotherapy prompted us to report this case. 

Keywords: Primary Diffuse Large B-Cell Lymphoma; Cranial Vault; Chemotherapy; Immuno Histochemistry.