Background: Depression is reported to be the commonest disorder in patients with Chronic Kidney Disease (CKD) but there is wide variability in the reported prevalence rates. Most of the studies have not employed valid diagnostic instruments specific for diagnostic guidelines.  The present study aims to measure depression in the patients of CKD using DSM-IV criteria. Aim: To evaluate the incidence of Major Depressive Disorder (MDD) according to the DSM-IV criteria in the patients having CKD. Methodology: 104 patients having CKD, with or without haemodialysis were assessed. The patients were assessed on MINI for the screening of depression. Co-morbid physical illnesses were screened for and recorded. Results: A total of 104 patients with CKD were assessed. 79.2% patients were on haemodialysis. Out of 104 patients screened 44.2 % screened positive for Major Depressive Disorder according to DSM-IV. Patients with MDD had significantly higher prevalence of Diabetes Mellitus (p = 0.009) and Obstructive Sleep Apnoea (p=0.016) compared to the patients without MDD.