The World Health Organization (WHO) defines chronic illness as the existence of a variety of physical health problems, which require health management for at least 1 year or even more than 10 years, such as hypertension, hyperlipidemia, and diabetes and asthma. Therefore, patients with chronic illness will encounter permanent changes in health status and are more likely to be under the menace of potential death. This menace is closely related to psychological distress, such as depression. Approximately 6–34% of the patients with chronic illness developed the symptoms of depression. Chronic illness is not only life-threatening to patients, but it is also a great burden to family and society.  Despite the regular treatment with medication, a significant proportion of patients does not respond to this treatment. Hence this review was aimed to associate the psychological well-being with the quality of life especially in patients suffering from severe asthma. The study was conducted among 30 patients at Chest OPD, Sri Ramachandra Hospital. The findings revealed that 40% had severe level of psychological distress; 53% had moderate level of psychological distress and 7% of them had well form of psychological well-being. Hence further research with large sample size is needed to findout the link between depression and sense of well-being.

Keywords: Asthma; Health Status; Quality of Life.