Background: Meningiomas constitute 13-26% of primary intracranial tumors and have predilection for females. Etiology is multifactorial including environmental causes. WHO classifies meningiomas into three grades based on various morphological criteria. Method: This study was carried out to correlate ER, PR expression, MIB-1 LI and traditional morphological prognostic markers of meningiomas. Sixty seven consecutive cases of meningioma, operated at a tertiary care neurosurgical centre, were analyzed for grade using routine Hematoxylin-Eosin stain; estrogen and progesterone receptor (ER, PR) status by immunohistochemistry; and proliferation index using MIB-1 labeling.Results: Majority were grade I neoplasms, with 11 being atypical and 05 anaplastic variants. The mean MIB-1 LI was 3.05%, 6.38% and 11.9% in grades I, II and III meningiomas respectively. ER expression was revealed in 20.89% cases with focal positivity, without any significance on correlation with grade, histology and gender. PR reactivity was found in 73% of the tumors. Higher positivity is found with low grade meningiomas, while high grade meningiomas are associated with negative PR expression. Unpaired t-test showed significant difference found in mean MIB-1 LI in PR positive and negative groups.Conclusion: PR and MIB-1 LI immunohistochemical staining emerged as useful supplements of routine histopathological assessment and can be used to provide additional information regarding behavior and response to treatment.

Keywords: Hormone receptor; Immunohistochemistry; Meningioma; Proliferation rate.