Indian Journal of Pathology: Research and Practice
Volume
7, Issue 3, March 2018, Pages 374-376
Original Article
An Immunohistochemical study of Human Papilloma Virus 16 (HPV 16) Expression in the Various Types of Carcinoma Cervix in the Rural Population of Tamilnadu
Sylvester N.a, Suban Mohammed Gouseb, K.R. Gopalakrishanc, B. Krishnaswamyd
aAssistant Professor, Department of Pathology, Kamineni Institute of Medical Sciences, Nalgonda, Narketpalli, Telangana 508254, India. bAssistant Professor & Division Head Division, Dept. of Pathology, Ibn Sina National College, Jeddah, Kingdom of Saudi Arabia. cReader dProfessor & Head, Dept. of Pathology, Rajah Muthaiya Medical College and Hospital Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India.
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Objective: To Study and observe the immunoexpression of HPV 16 in the various typesof carcinoma cervix (Ca Cx) diagnosed in the rural tertiary care hospital in Tamilnadu.Materials & Method: The biopsies 243 cases of carcinoma cervix which was diagnosedin the Division of Pathology for the period of 5 years from January 2011 and December2016were included for the study. A Total of 43 cases were selected for theimmunohistochemical staining (AVIDIN-BIOTIN Method) to find the immunoexpressionfor HPV 16. A positive immunoexpression of 48.8% was observed for HPV 16 out of which51.3% are Squamous cell carcinoma and 1 case of Carcinosarcoma of cervix. 6 cases ofAdenocarcinoma and 1 case of small cell carcinoma was negative for HPV 16immunoexpression.Conclusion: Regular and periodic screening for all women above 30 years for cervicalcancer and Screening of the most common high-risk HPV types should be done. Cervicalcancer awareness programs should have regular follow up.
Keywords:Carcinoma Cervix; High Risk Human Papilloma Virus; HPV 16;Immunoexpression.
Corresponding Author : K.R. Gopalakrishan, Reader, Dept. of Pathology, Rajah Muthaiya Medical College and Hospital, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India.