Background: Seventh most common tumor is urinary bladder tumor among which urothelial carcinoma constitutes 90% of primary bladder tumor. Both neoplastic and non neoplastic diseases produce clinical signs and symptoms. Though the non-neoplastic diseases are disabling, the neoplastic lesions are the source of mortality. This study was conducted to analyze frequency and clinical features of various histopathological lesions of bladder tumors. Materials and Methods: this retrospective study was carried out in the department of pathology, Narayana medical college, Nellore. Clinicopathological data of bladder biopsies received from urology department were analyzed. Results: 68 bladder biopsies were studied. Among them 53 cases were neoplastic and 15 cases were non neoplastic lesions. Both neoplastic and non-neoplastic lesions showed male predominance. Neoplastic lesions were noted in the age group of 61-70 years (28.3%) . Non-neoplastic lesions showed predominance in the 31- 40 years age group. Among the neoplastic lesion low grade papillary urothelial carcinoma invading lamina propria constituted maximum number (32.1%) followed by high grade urothelial carcinoma invading muscle layer (24.4%). Few rare tumors like urachal adenoacrcinoma, mucinous adenocarcinoma, sarcomatoid urothelial carcinoma were also encountered in our study. Among the nonneoplastic lesions, granulomatous cystitis were maximum (46.6%) followed by non-specific chronic cystitis, cystitis cystica, cystitis glandularis and eosinophilic cystitis. Conclusion: In the bladder neoplastic lesions are more common than non-neoplastic lesions. Among the neoplastic lesions, papillary urothelial neoplasms are commonest. Grading of urothelial carcinoma along with presence or absence of muscle invasion is an important prognostic factor. Clinical signs and symptoms like haematuria should not be neglected as it may lead to advanced stage of neoplastic lesions at the time of diagnosis.

Keywords: Bladder Lesions; Urothelial Tumors; Non Neoplastic Lesions.