Introduction: Prostatism is a common disease in the geriatric age group. Benign prostatic hyperplasia and Carcinoma of the prostate are increasingly frequent with advancing age. Aim of the present cross-sectional study is to evaluate the complete spectrum of histopathological types of various prostatic lesions. Materials and Methods: A total of 75 prostate biopsies were received from January 2016 to December 2016 in the Department of Pathology, in a tertiary care hospital, Uttar Pradesh. Routine Hematoxylin and Eosin staining was performed. Reporting of malignant cases included Gleason’s grade and score. Relevant clinical data including the age, presenting complaints, and radiological findings were documented for all the cases. Results: A total of 75 prostate biopsies were received, the mean age was 63.04 years. Most common presenting complaint was difficulty in micturition. Study included, 56 (74.66%) cases of Benign prostatic hyperplasia alone and 5 (6.66%) were of Adenocarcinoma. Chronic Prostatitis 6 (8%) was the most common non-neoplastic lesion associated in cases of benign prostatic hyperplasia. Two (2.66%) cases were of benign prostatic hyperplasia along with Basal cell hyperplasia. One (1.33%) case each of granulomatous prostatitis, cystitis glandularis (urothelium), and squamous metaplasia were associated with benign prostatic hyperplasia. One (1.33%) case each of Prostatic intraepithelial neoplasia, Undifferentiated carcinoma, and post operative spindle cell nodule were also noted. Conclusion: Benign prostatic hyperplasia is the most commonly encountered prostatic lesion. In spite of availability of various investigations, a definitive diagnosis of prostatic lesions can be made by histopathological study only.

Keywords: Benign Prostatic Hyperplasia; Chronic Prostatitis; Basal Cell Hyperplasia; Prostatic Intraepithelial Neoplasia; Carcinoma Prostate; Post Operative Spindle Cell Nodule.