Introduction: Women worldwide suffer from gynaecological and obstetric disorders that require hysterectomy as a treatment option. Hysterectomy forms the major bulk among the specimens received in our histopathology laboratory, hence this study was undertaken to know the incidence and also understand the variety of lesions in the hysterectomy specimen. Materials and Methods: The present study was done in the Department of Pathology, KBNIMS, Kalaburagi, from July 2014 to June 2016. All types of hysterectomy specimens (with or without adnexa) received during this period, were studied. Results: Total number of hysterectomy specimens received was 269. Out of 269 cases, non-neoplastic lesions were 141(52%), benign tumors were 114 (43%) and malignant tumors were 14 (5%). One case of tuberculosis of the endometrium was diagnosed. Malignant lesions were 3(1.2%), 2 cases of endometrial adenocarcinoma and 1 case of endometrial stromal sarcoma. Incidence of leiomyoma in present study was 31.8% (86/269) with mean age of 42.42 years and incidence of adenomyosis was 32%. Among 6 malignant tumors of cervix, 4(82%) cases were squamous cell carcinoma, 1 (9%) case of adenocarcinoma, 1 (4.5%) case of adenosquamous carcinoma. One of primary adenocarcinoma of fallopian tube was diagnosed,which was not diagnosed clinically. One case of mucinous cystadenocarcinoma with metastasis to the serosa of the uterus and to the colon, was diagnosed. Conclusion: Study of hysterectomy specimens is fascinating, as a variety of lesions are encountered. This specimen needs to be thoroughly studied, in order to know the different types of lesions in the female genital tract.

Keywords: Hysterectomy; Leiomyoma; Squamous Cell Carcinoma; Tuberculous; Endometritis.