Introduction: The morphologic pattern in the various granulomatous diseases may be sufficiently different, to allow reasonably accurate diagnosis by an experienced pathologist, however there are so many atypical presentations, that it is always necessary to identify the specific etiologic agent by special stains for organisms, by culture methods and by serological studies to exclude an infectious cause. Methodology: The clinical assessment of the patients were done by the Dermatologists. The skin biopsies were taken from the most prominent lesion or from the anaesthetic area depending on clinical diagnosis. Results: Leprosy formed the largest population, of the total 58 cases were Leprosy. The next in frequency was fungal granulomas. Out of the total 13 cases, in 9 cases (69.2%), a diagnosis of chromoblhomycosis was made, in one case the diagnosis was Histoplasmosis (7.7%). Conclusion: A detailed evaluation of good H&E stained sections could offer many diagnostic points for the accurate aetiological classification

Key words: Granulomatous; Histopathology; Leprosy.