Introduction: Nephrotic syndrome (NS) is caused by increased permeability of the glomerular capillary wall for proteins. Aims and Objectives: To Study biochemical status of serum and urine in patients of Nephrotic Syndrome. Methodology: The present study was carried out in department of Pathology, ACPM Medical College Dhule. The period of study was one year. Diagnosed cases of nephrotic syndrome of different age and sex in the hospital during one year period were included in study. Diagnosis of nephrotic syndrome was recommended by international study of kidney disease for diagnosis.Result: Age and sex wise distribution of 84 cases of nephrotic syndrome is tabulated in table. Maximum number of patient 54(64.28%) were-observed in 0-10 years age groupthe prevalence of nephrotic syndrome decreases as age advanceThe various Biochemical serum values were (Mean ±SD) i.e. Total proteins (g/dl) were 3.32 ± 2.6 and Albumin (g/dl) was 1.52 ± 0.9; Sr. Cholesterol (mg/dl) was 235 ± 1.2 and Total antioxidants (mmol/L) were 1.77 ± 0.92; Homocysteine (umol/L) was 18.11 ± 4.12 and Vit.C (mg/L) was 0.52 ± 0.42.The majority of the Patients were having Urine Protein values i.e. Total urine protein g/24 hrs. in 2-2.9 range were 33(39.28%) followed by 3-3.9 were 33. (39.28%); 4- 6 were 17(20.23%) and >6 were 1(1.19%). Conclusion: In Nephrotic Syndrome, various serums biochemical values like total Proteins, Total antioxidants and Vit.C levels were decreased while Homocysteine level was increased and in urine there was proteinuria.

Keywords: Total Proteins; Total Antioxidants; Homocysteine; Proteinuria.