Introduction: Infections of the kidney are the common indication for the nephrectomy. Nephrectomy is a common urological procedure done for a variety of conditions like chronic infection, obstruction, injury and neoplasms. Aim and objectives: To study the various non–neoplastic lesions of Nephrectomy specimens. Material and Methods: The prospective study from the period of January 2013 to December 2015 was conducted in the Department of Pathology, Santhiram medical college, Nandyal. All the Nepherectomy specimens were analysed. Results: A total of 72 cases were studied. 62 cases were non neoplastic and 10 cases were neoplastic lesions. Chronic pyelonephritis was the predominant lesion in female. Conclusion: Infections in the kidney were common cause of chronic pyelonephritis in females. The chronic pyelonephrtis is the common indication for the nephrectomy.

Keywords: Chronic Pyelonephritis; Nephrectomy; Non – Neoplastic Lesions