Ashmari (Urolithiasis) is a frequently encountered urological disorder in its different forms. Since many years it has been a challenging problem facing by the urologist to combat the disease and find its solution an experimental study has been carried out. In the present study the alcoholic extract of the whole plant and the fresh juice of the leaves of the plant Pasanabheda (Bryophyllum pinnatum) were studied for its antiurolithiatic activity against experimentally produced urinary bladder stones in albino rats in the laboratory. The entire study was conducted in three groups of 08 rats. Bladder stone was produced by implanting the glass bead in the urinary bladder of all rats as a foreign body. Group-A rats were treated with plain water, group-B rats were treated with alcoholic extract of the drug whereas, group-C rats were treated with fresh juice of the leaves of the plant in calculated doses, for a period of 30 days. In this research, different parameters of blood and urine, related to the pathogenesis of the stones, were tested. The trial drug has clearly shown the effectiveness in increasing the urine output, lowering the pH of urine, decreasing the excretion of urinary calcium and phosphorus and preventing the growth of urinary bladder stone and over all its formation in experimental model of albino rats. Key words: Ashmari, Urolithiasis, Pasanabheda, Bryophyllum pinnatum, Antiurolithiatic activity, Urinary bladder stones.Ashmari (Urolithiasis) is a frequently encountered urological disorder in its different forms. Since many years it has been a challenging problem facing by the urologist to combat the disease and find its solution an experimental study has been carried out. In the present study the alcoholic extract of the whole plant and the fresh juice of the leaves of the plant Pasanabheda (Bryophyllum pinnatum) were studied for its antiurolithiatic activity against experimentally produced urinary bladder stones in albino rats in the laboratory. The entire study was conducted in three groups of 08 rats. Bladder stone was produced by implanting the glass bead in the urinary bladder of all rats as a foreign body. Group-A rats were treated with plain water, group-B rats were treated with alcoholic extract of the drug whereas, group-C rats were treated with fresh juice of the leaves of the plant in calculated doses, for a period of 30 days. In this research, different parameters of blood and urine, related to the pathogenesis of the stones, were tested. The trial drug has clearly shown the effectiveness in increasing the urine output, lowering the pH of urine, decreasing the excretion of urinary calcium and phosphorus and preventing the growth of urinary bladder stone and over all its formation in experimental model of albino rats.

Key words: Ashmari, Urolithiasis, Pasanabheda, Bryophyllum pinnatum, Antiurolithiatic activity, Urinary bladder stones.