Background: The quality control assessment of Poly- herbal formulations is of great significance in order to justify their acceptability in modern system of medicine though the drug may be therapeutically potent. Ayurveda and its rapidly increasing use by public has given rise to many newer issues and challenges. Ayurvedic formulations prepared by several manufactures are guaranteed to carry out the quality control test as per preliminary guidelines given by CCRAS (Central Council of Research in Ayurveda & Siddha). Though the standards are followed, still the variability in their results has been observed when compared between same formulations. Bilwadi Agada is one such Poly- herbal formulation consisting of 13 drugs & treated in Garavisha & Jangama visha etc. The condition which produces ailments like Pandu, Krusha, Alpaghni, Kasa, swasa, Aridta ,when triggering factor are congregate. An attempt is made here to compare Bilwadi Agada prepared by GMP certified pharmacy within house preparation. Results revealed that the both the samples differ in their organoleptics, pH & Physico- chemical properties, Thin layered chromatographic study showed ,major difference was seen in disintegration time & hardness of sample A i.e., hardness is 7.1 but none of them disintegrates in 35min, whereas sample B hardness is 4.2, but disintegrates in 15min. The physic chemical data of this comparative study assists in maintaining the standard limits of Bilwadi Agada. 

Keywords: Bilwadi Agada; Garavisha; Poly-Herbal Formulation; Physico-Chemical Analysis; TLC.