Premature ageing is accelerating mode of ageing, which create early symptoms of ageing and age related diseases depending upon its rate determining by various factors. Premature ageing is strongly affected by environmental, lifestyle and some disease conditions which are related to ageing but not due to ageing itself. The objective of rasayana drugs is to improve nutritional state of body by which healthy youthfulness and longevity is expected. All ingredients of Amalakayas Rasayana (AR) are known to have antioxidants, free radical scavenging activity, adaptgenic activity, and immune modulatory activity and to enhance production of endogenous antioxidant enzymes. The study which was single blind clinical research was designed to assess the efficacy of AR on mental health on 51 persons who are clinically aged than their actual age and to evaluate it therapeutically as an antiageing medicine. It was observed that some premature ageing patients had tension (21.66%), depression (7.5%) and anxiety (1.66%). On Both Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS), GIT symptoms (76.92%), depressed mood (39.58%), and insomnia (38%) was improved. The improvement of tension, insomnia, depressed mood, respiratory symptoms and GIT symptoms were statistically highly significant (p<0.001). Totally, AR showed moderate improvement on HARS in 28.13% patients, whereas on HDRS in 19.35% patients. On abnormal Manasa Bhava, AR improved priti in statistically highly significant manner (p<0.001), whereas chinta and vishada in significant manner (p<0.01). Keeping all these facts in view, it can be concluded that observed results on parameters of HARS and HDRS and abnormal manasa bhava are due to anti stress and adaptogenic activity and also due to medhya effect of Amalakayas Rasayana. 

Keywords: Hamilton anxiety rating scale; Hamilton anxiety rating scale; Manasabhava; Amalakayas rasayana; Premature ageing.