This letter to editor aims to enlighten the role of gender in diabetic peripheral neuropathy (DPN), in terms of prevalence, associated risk factors in pathogenesis and as a confounding factor in clinical trials on pharmacological and non-pharmacological management. The existing studies indicated that gender had following role in DPN; determined the onset, impact of diabetes, painful v/s painless presentation, electrophysiological measures, co-occurrence of carpal tunnel syndrome, medical and surgical treatments and influenced renal function. 

Keywords: Gender; Sex; Diabetic neuropathy.