Introduction: Worldwide Infertility rate prevails around 8–12% of all couples; approximately 80 million are infertile. Investigations for infertility are meant to intervene into the modifiable/treatable causes. In India 10–15% of couples are infertile. Therefore, the present study was undertaken to investigate the morphological patterns of endometrial tissue in women with primary infertility. Materials and Methods: The study included 16 cases with complaints of infertility (secondary). The premenstrual D&C was done to obtain endometrial biopsy. The present prospective study was a descriptive study and the values are mentioned in percentages. Results and Discussion: In present study a total of 16 cases were studied. Out of which 8 cases (50%) belonged to the 25–30 yrs age group. The predominant morphological pattern was that of secretory endometrium seen in 6 cases (37.5%) as opposed to proliferative, endometritic or tubercular pattern. The predominant menstrual pattern recorded was Regular; seen in 10 cases (62.5%) as opposed to irregular or menorrhagic patterns. Conclusion: The endometrial biopsy has a great role in screening the cases of infertility as it helps to assess the information about ovulation, ripening of the endometrial tissue and other abnormal endometrial reaction, hormonal imbalance. This is the only method to label the diagnosis of endometrial tuberculosis in an apparently healthy female.