Xanthogranulomatous inflammation of female genital tract is extremely rare entity. Very few cases have been documented in literature. It is an uncommon cause of chronic destructive process of the normal tissue of the affected organ. We presented 3 cases of xanthogranulomatous affection of tube and ovary in 27 years, 30 years and 74 years postmenopausal woman with unilateral hydronephrosis without having history of all known predisposing factors like pelvic inflammatory disease (PID), endometriosis, intrauterine contraceptive devices (IUCD). Their clinical examination, radiological evaluation, tumor markers, were likely to get confused with neoplasm in first case and large uterine fibroid mass in second case. Peroperatively It was found tubo-ovarian mass. On histopathological examination it came out with xanthogranulomatous inflammation of tube and ovary. So in this clinical scenario we should keep xanthogranuloma as one of differential diagnosis. It is characterized by the presence of lipid-filled macrophages with admixed lymphocytes, plasma cells, and neutrophils.