Menopause is a part of natural aging process that causes a variety of physiological and psychological changes in the life of women. Various psycho social factors like lifestyle, health, culture, previous mood disorders all impact on menopause transition. Rapid changes in female reproductive hormones are implicated to cause fear, anxiety, depression and mood swings. However, insufficient coping abilities and poor adaptation to stress predisposes vulnerable women to emotional instability. Menopause is an unavoidable stage of life and acceptability of this fact depends on awareness, attitude, practices and health of women. Along with appropriate pharmacological treatment; lifestyle modifications and psycho-social support would go a long way to help women to steer through this phase of life with a sound mind.