Context: Preterm delivery is one of the most important causes of perinatal morbidity and mortality. Early detection of infection is most important during the conservative management of patients with preterm labor. CRP is one of the sensitive markers of systemic inflammation and hence, a suitable marker for predicting risk of preterm delivery. This study was thus planned with an aim to establish the association between maternal plasma CRP levels in pregnancy and risk of preterm delivery. Aims: To study the association between the level of CRP and preterm labor and PPROM. Methods and Materials: The study included 150 women with singleton pregnancy with gestational age between 28-36+6 weeks who experienced PTL and PPROM. The study was conducted over a period of 24 months from November 2018 – October 2020. Venous blood samples were drawn from these patients and Serum CRP level was estimated. Results: 103 (68.7%) out of 150 patients enrolled in the study had elevated levels of Serum CRP >/=7 mg/L thus showing a significant statistical relation between S.CRP and PTL, PPROM. The mean S.CRP value being 12.0 ± 5.9 mg/L. The relation between S.CRP and its variation with gestational age was also found to be highly significant, showing the mean value of S.CRP to be highest among gestational age between 28-30 weeks and lowest among 35-36 weeks. Conclusions: CRP can thus be established as a biochemical marker for prediction of PTL and can be used as a non-invasive screening tool to detect cases that are at risk of PTL and PPROM.