AbstractAims and Objectives: • To study factors associated with intra-partum meconium stained liquor &feto maternal outcome. • To compare the fetal outcome in relation to MSAF and clear amniotic fluid also in thick v/s thin meconium. Material and methods: This study prospective of 100 subjects was done in a tertiary care hospital over six months. Fifty with MSAF detected at any time during the course of labour or prior to it were enrolled in the study group. The inclusion criteria were, a singleton, cephalic, term pregnancy without anomalies. For control, the next woman giving birth following the index patient who satisfied similar inclusion criteria and had clear amniotic fluid was selected. Result: Among risk factors, preeclampsia p=0.04, fetal growth restriction p=0.05, fetal distress p=0.0002 and labour dystocia p=0.0009 were found to be statically significant. Caesarean section was considerably higher in patients with MSAF, p=<0.001. 66% patients with MSAF had FHR abnormalities as compared to 2% controls. 47.6% babies with thin MSAF and 75.8% of babies with thick MSAF had nonreassuring CTG. 42% patients had thin meconium and 58% patient had thick meconium. Conclusion: Women with prelabour or early labour rupture of membranes were noted to have a higher association with MSAF. Presence of thick MSAF, necessitates intensive monitoring of labour including surveillance of fetal wellbeing to optimise the neonatal outcome. Vigilance during labour and timely referral to higher centre/ availability of trained staff for neonatal resuscitation and management is the key to reducing neonatal morbidity and mortality associated with MSAF.