Background: For Endometrial biopsy Pipelle sampling can be done as an office procedure. In this study Pipelle is being studied in terms of specificity and sensitivity for diagnosis and for replacing other methods of sampling. Methods: 60 patients underwent pipelle endometrial sampling on OPD basis followed by hysteroscopic evaluation and endometrial sampling in the same menstrual cycle . Histopathology report of both the pipelle and hysteroscopic endometrial samples were compared and statistical analysis done. Results: In subjects with proliferative Endometrium in Hysteroscopy 93.9% were diagnosed by pipelle sample, In Secretory Endometrium in Hysteroscopy, 83.3% were diagnosed by pipelle sample, Out of 33 subjects with Disordered Endometrium in Hysteroscopy, 100% were diagnosed by pipelle sample. In the sample Hyperplasia in hysteroscopy, 100% were diagnosed by pipelle sample. In samples without simple Hyperplasia in Hysteroscopy, 98.3% were negative in pipelle sample and 1.7% were positive in pipelle sample (False Positive). In Adenomatous Polyp in Hysteroscopy 20% were diagnosed by pipelle sample and 80% were negative (False Negative). In Cystoglandular Hyperplasia in Hysteroscopy, 100% diagnosed by pipelle sample. Conclusion: Pipelle is 100% sensitive in diagnosing premalignant changes in the endometrium. Hence pipelle, a cost effective non-invasive procedure, can be used as a first line method to diagnose endometrial pathology in abnormal uterine bleeding.