Background: Othello syndrome (OS) also known as morbid jealousy has been associated with substance use disorders, various psychiatric and neurological conditions. Case Summary: Here, we present a case of a 47 year old male who developed delusion of infidelity as sequelae of a right parietal lobe venous infarc. Discussion: Our patient had developed OS subsequently after right parietal lobe infarct. However, not many case reports have been previously documented wherein a patient developed delusion of infidelity with parietal lobe lesions. Conclusion: Hence, our case may be indicative of role of parietal lobe in the pathophysiology of delusion of infidelity, which warrants further research.