Background: Biomedical waste is waste which produce during diagnosis, treatment (medical, surgical), and immunization. All small and big health care centres are generators of Biomedical Waste Management. There are approximately 75-90% non-risky waste and 10- 25% risky waste that cause various injuries and communicable disease. Objectives: To assess the knowledge, practices and reasons of noncompliance among Health care Personnel regarding Biomedical Waste Management; to find out the relationship between knowledge and practices of Health care Personnel regarding bio-medical waste management; to determine the association of Knowledge, Practices with selected variables. Method: Non-experimental descriptive Survey design was used in this study. 148 Health Care Personnel were selected by the total enumeration sampling technique. The tools for data collection were structure Knowledge Questionnaire to assess knowledge, Observation  checklist to assess the Practices, Rating Scale to assess the Reasons of non-compliance Biomedical Waste management. Result: showed that the doctors (32.1%) and nurses (63.6%) had very good level of knowledge and fourth class workers (87.5%) had poor level of knowledge regarding Biomedical Waste Management. doctors (90.9%) and nurses (76.4%) had poor level of Practice while fourth class workers (57.5%) had poor level of Practice.There is no co- eletion between Knowledge and practice of health care Personnel.The association between knowledge, practices of health care personnel and selected variables was found non- significant at 0.05 level of significance. Conclusion: Knowledge and practices of health care personnel is not adequate insufficient supply of resources, Lack of awareness inadequate man power were reasons of non-compliance regarding biomedical waste management.