Aim: To evaluate the diagnostic utility of Serum Cancer Antigen-125 (CA125) and Carcino embryonic antigen (CEA) and LDH levels in patients suffering from Ovarian Cancer.  

Study Design: A hospital based cross sectional study was conducted on patients attending the Out Patient Department of Gynecology of SGRR Medical College Dehradun (Uttarakhand) during a period of 8 months from June 2017 to January 2018. A total number of 70 cases of ovarian cancer etween the age group 15-75years were selected randomly for the study. 

Inclusion criteria: all patients underwent a tertiary transabdominal and transvaginal sonography and 70 cases of ovarian cancer were selected for the study.

Exclusion criteria: was age less than 15 years and more than 75 years, pregnant women, other Gynecological malignancies, TB, Diabetic Mellitus etc. 

Methodology: All the selected cases of ovarian cancer were subjected to clinical chemistry analysis of serum CA 125, CEA & LDH which was performed on fully automated analyzer 5600 of Orthoclinical Diagnostics.

Result: The serum levels of CA125, CEA and LDH were found to be very high along with a high CA125/CEA ratio. Conclusion: Our results show the importance of CA125, CEA, CA125/ CEA ratio and LDH in the diagnosis and monitoring the efficacy of treatment. Combination of serum tumour markers in the diagnosis of ovarian malignancy.