Burns can severely damage a patient's physical and mental health. We should consider pain, hospital stays, lost workdays, and financial strain while handling these patients. Burn patients need rapid specialist care to reduce morbidity and death. Heparin is anti-inflammatory, allergic, histaminic, serotonin blocking, and proteolytic enzyme-blocking. Topical forms have been used to prevent burn extension, limit skin tissue loss, promote quicker healing with fewer contractures, relieve pain, reduce tissue oedema and weeping, prevent infection, and promote revascularization, granulation, and epithelialization of deeply burned tissue. We discuss topical heparin and burn care in this review.