Background: Deliberate self poisoning are commonly encountered cases at most of the rural Indian Government hospitals. Along with associated morbidity economic burden to the country is immense. Bread winners of family being affected at large scale has socio-economic impact on dependents. Objective: To study the Clinical and Etiological profile of a patients presenting to emergency department in a rural Indian Government hospital with deliberate self poisoning. Material and methods: This was conducted in a rural government district hospital Chamarajanagar, over a period of one year. A total number of 156 patients aged more than 15 years of both genders were included. After initial resuscitation and antidote treatment along with other symptomatic treatment. Detailed history, clinical examination and nature of poisonous material was studied. Psychiatric counselling was done before discharge. Accidental and homicidal poisoning patients were excluded. Results: Out of 156 patients 94 were males (60.25%) and 62 were females (39.79%). Among males age group between 35 to 45 years were most common (38.2%), where as in females age group between 25 to 35 years were most common (38.7%). At extreme age group i.e. between 15 to 25 years and more than 65 years percentage of female patients outnumbered male counterpart. Among clinical symptoms generalised weakness and altered sensorium was most common and Constricted pupil was the most common sign. Conclusion: Deliberate self poisoning leads to significant morbidity and mortality among rural population. Limiting easy access to poisonous  material through government regulations and policies and increasing the public awareness about its ill effects through health education needed.