Introduction: Typhoid fever is a very common disease of the developing world, being a major public health concern in countries like India. The antibiotic susceptibility scenario varies significantly across regions. In India the pictures are conflicting. Objective: The objective of the study was to identify the antibiotic susceptibility pattern of S. typhi among registered patients in a tertiary care hospital in India. Materials and Methods: The study was done at Peerless Hospital and B. K. Roy Research Center which is a tertiary care Hospital in Kolkata. This was a record-based retrospective cross-sectional and descriptive analysis using SAS software version 9.3.2 during 2012 to 2013. The patients included in the study were admitted in the hospital with accessible medical records. Results: Among 86 recruited patients, the average age was 43.14 years and 59.30%, subjects were male. Overall, fever (91.86%) was the most common symptom followed by nausea (84.88%), diarrhea (83.72%), vomiting (63.95%) and body ache (51.16%). Of total 86 blood samples, 23 (26.74%) samples were blood culture positive. Of these 23 blood culture positive samples, 20 (23.26%) samples were positive for Salmonella Ser.typhi and 3 (3.49%) samples were positive for Salmonella Ser. paratyphi. Overall, among the 23 blood culture positive subjects, isolated bacterial strains were 100% sensitive to ampicillin, amoxicillin/clavulanic acid, piperacillin/tazobactum, cefoperazone/sulbactam, ceftriaxone, cefepime, ertapenem, imipenem, meropenem, tigecycline and colistin and 100% resistant to cefuroxime axetil, cefuroxime, amikacin and gentamycin. Conclusion: blood culture positivity and resistant pattern to commonly used antibiotics for S. typhi was substantially high among the patients admitted in a tertiary care hospital in eastern part of India and a standardized protocol for proper antibiotic treatment and management of the patients infected with S. typhi is warranted.

Keywords: Typhoid; Antibiotic; Salmonella Ser. typhi.