Ascending paralysis is a rare neurological manifestation characterized by progressive weakness that starts in the lower extremities and ascends towards the upper body. GuillainBarré Syndrome (GBS) is a common cause of ascending paralysis and is typically preceded by an infection. We present two case reports, who presented with ascending paralysis, which was initially suspected to be GBS. However, further evaluation revealed an underlying neuropathy contributing to the clinical presentation with a vasculitic etiology.

This case highlights the importance of considering alternative etiologies when evaluating patients with ascending paralysis, as over lapping clinical features between GBS and neuropathies can present diagnostic challenges. Early recognition and prompt initiation of appropriate treatment are crucial for favorable patient outcomes.