Abstract Electrolyte problems are one of the most common cause of morbidity and mortality in the sick patients coming to the Emergency. Electrolytes measured in central lab usually takes 30-60 minutes or more whereas point of care device can give results within 5 to 10 minutes, however different instruments available and their values varies accordingly. Therefore, this study was done to investigate whether electrolyte i.e. sodium and potassium levels assessed using point of care device and auto analysers were equivalent. Methods: We prospectively studied patients admitted from Emergency Department between January 2021 to October 2021. We had taken 60 paired convenience samples and analysed sodium and potassium levels in point of care device (epoc POC device, Siemens) and in Central Lab Auto Analyser (Siemens Dimension RxL Max Integrated chemistry analyzer or in Johnson & Johnson chemistry analyser model number 51 FS). Statistical method to compare the data included Boxplot view, Regression line, Spearman’s correlation coefficient’s, paired t-test for potassium and Wilcox test for sodium correlation, Regression equation, Deming regression and Bland Altman plots.