Sickle Cell Anemia is a complex inherited autosomal recessive Hemoglobin disease/disorder. It is not only generate the illness but also responsible for stigma in the society. Through the stigma the patients and their family members become more sufferers throughout their life. The mismanagement causes death before medication of the patients. So, there is a need of awareness about sickle cell anemia for various groups of the people like medical personal, researcher, social workers, psychologists, family members and patients. This paper reflects the sickle cell anemia history, origin and distribution in Bastar district of Chhattisgarh. This paper also highlights the knowledge and attitude of the patients with Sickle Cell Disease. The patients’ level to policy level recommendations would be the vital for the need of the patients and their families as well as will create an approach to medical attention.