In the human body heart play a vital role to manage the function of circulatory system. If the brain stops working, the heart can manage the body, but if the heart stops working, nothing can manage the body. Heart disease increase day by day and death rate also increased due to heart disease as compare to brain disease. Deaths due to cardiovascular diseases increases from 13 lakh to 28 lakh in 2016. A heart transplant is the replacement of a person's diseased or damaged heart with a donor's healthy heart transplants are performed when other treatments possibility is not available leading to heart failure. Heart transplantation its having two types orthotopic and hetrotopic. Goal of cardiac transplantation is to improve the patient condition and save the patient life.

Keyword: Heart; Transplantation; End-stage cardiac disease; Orthotopic Heterotopic.