Background: The patient in the intensive care unit often requires mechanical assistance to maintain airway patency. Current generations’ ventilators incorporate computerized systems to deliver and monitor ventilator parameters. So nurses need to gain in-depth knowledge and advance skills to provide the quality nursing care of a patient on mechanical ventilator. The aim of this research was to study effect of learning package on nurse's knowledge and skills regarding care of a patient on mechanical ventilator among staff nurses. Material and Methods: One group pretest-posttest pre-experimental research design was used to assess the effectiveness of learning package on knowledge and skill regarding care of patient on mechanical ventilator among 60 staff nurses who were selected by non-probability convenience sampling technique. Structured knowledge questionnaire and structured observation checklist were used to assess the knowledge and skill of staff nurses respectively. Both descriptive and inferential statistics were used to analysis of data. Findings: Majority 34 (56.66%) of staff nurses were male and 55% and 90% were between the age group 21-25years and having diploma in nursing respectively. The mean pre-test knowledge score and skill score was 21.6±3.9 and 25.0±3.3 respectively whereas; posttest knowledge and skill score were 30.4±3.5 and 31.6±3 respectely. The level of knowledge and skill regarding care of patient on mechanical ventilator was significantly higher after receiving the learning package and knowledge and skill was significantly correlated. Conclusion: The study concluded that learning package lead to significant improvement in nurse's knowledge and skills about care of patient on mechanical ventilator as computed‘t’ test was significant at 0.05 level of significance. 

Keywords: Learning Package; Knowledge; Skill, and Staff Nurses.