Limbal stem cell maintains the homeostasis around the cornea. Limbal stem cell deficiency (LSCD) occurs either by congenital or acquired causes due to the destruction of niche in the complex microenvironment. The diagnosis of LSCD is made on clinical findings and newer methods such as imaging modality, molecular markers and impression cytology which has led to more effective grading of the severity of LSCD and its strategic management planning. This article reviews the clinical presentation, newer techniques for diagnosis and management of LSCD.

Keywords: Limbal stem cell deficiency (LSCD); Diagnosis; Imaging modality; Molecular markers; Cytology.