Purpose: Evaluation of endothelial cell density (ECD) in patients of pseudoexfoliation (PEX) syndrome with glaucoma (PEXG) and without glaucoma using specular microscopy. Material and methods: The study included 142 patients (236 eyes). In this group of patient we identified 166 eyes with PEX syndrome (80 with glaucoma, 86 without glaucoma) and 70 eyes without PEX syndrome. ECD was measured in each eye by specular microscopy. Results: ECD in eyes with PEX syndrome without glaucoma (2286 ± 348 cells/mm²) and in eyes with PEXG (2237 ± 353 cells/mm²) was lower than in the control group (2513 ± 265 cells/mm²) (P< 0.001). Conclusion: This research shows that in eyes with PEX syndrome, both with and without glaucoma, ECD was statistically significantly lower than in the control group.

Keywords: Psedoexfoliation syndrome; Pseudoexfoliation glaucoma; Endothelial cell density; Specular microscope.