Introduction: Diabetes mellitus is one of the most common systemic diseases in the world. Diabetic patients are exposed to increased oxidative stress. However very few studies have measured and compared oxidative stress, antioxidant status in patient of diabetes with hypertension. Hence present study was conducted, which was aimed to measure antioxidant levels (Vitamin C, vitamin E) and oxidative stress (Malondialdehyde-MDA level) in type 2 diabetic patients, in type 2 diabetic patients with hypertension and to compare them with age and gender matched healthy controls. Male volunteers of 40-60 years were divided into Group I - 30 normal healthy controls, Group II - 30 patients having type II diabetes mellitus since 3 to 6 years, Group III - 30 patients having type 2 diabetes mellitus along with hypertension since 3 to 6 years. Serum levels of MDA were estimated by method described by Buege and Aust. serum levels of Vitamin C and vitamin E were estimated by method described by Ayekyaw and Baker respectively. Serum MDA levels, serum Vitamin C and vitamin E levels compared by applying appropriate statistical test. We found statistically highly significant increase (<0.001) in serum MDA levels and significant decrease (<0.05) in both serum Vitamin C levels and serum vitamin E levels in patients of diabetes with hypertension as compared to patients having only diabetes. Conclusion: Our study showed that patients having both diabetes and hypertension have increased oxidative stress than patients having only diabetes. So, these patients will be more susceptible for developing complication related to oxidative stress. So proper precaution in the form for antioxidant supplementation to these patients can help them to live better quality of life.

Keywords: Hypertension; Malondialdehyde; Type 2 Diabetes Mellitus; Vitamin C; Vitamin E.