This short communication article was aimed to provide an evidence-informed overview and a scoping review of the role of mitochondrial function/dysfunction in diabetic peripheral neuropathy (DPN). From the reviewed studies, it is apparently evident that mitochondria played a comprehensive role not only in predisposing oxidative stress but also in programmed cell death or apoptosis in DPN.

Keywords: Mitochondrial function; Oxidative stress; Pathophysiology; Diabetic neuropathy.