Poor knowledge about pain and underestimation of patients’ ability to understand pain-related information represented barriers to reconceptualization of chronic pain problem and hence this short communication was aimed at providing a descriptive summary of evidence for pain neurophysiology education (PNE) as an effective intervention through studies retrieved from PubMed. PNE was shown to be effective in one study on fibromyalgia, four studies on chronic low back pain (one pilot study, one single case study, one randomized controlled trial, one systematic review), and one study on chronic whiplash. The ensuing paradigm shift towards mechanism-based classification of pain and mechanism-based physical therapy warranted establishing mechanism-based treatment guidelines so that treatments not only aim at symptom control but also enhancement of quality of life in people.

Keywords: Manual therapy; Applied physiology; Therapeutic physiology; Clinical physiology; Pain neurophysiology.